Yolk sac (endodermal sinus) tumors are rare malignant germ cell tumors that usually
arise in the ovary or testis and rarely develop in extragonadal sites. These tumors have
often been associated with teratomatous areas.
An autopsy case of a mixed malignant germ cell tumor (endodermal sinus tumor and
mature teratoma) is reported, in a fourteen-month-old female child.
On autopsy, a large protruding mass is located in the sacrococcygeal region, measuring
about 15 cm in diameter.
This tumor mass is invaded into the left side of the gluteus muscle and the left ovary.
Multiple metastatic nodules are also demonstrable in the liver.
Microscopically, this tumor mass shows reticular areas formed by a loose meshwork
lined by flat or cuboidal cells, papillary formations with Schiller-Duval bodies, and solid
undifferentiated areas. In some sections, it also reveals various elements derived from
trigerm layers, composed of skin appendages, bronchial tree, cartilage, bone and central
nervous tissue.
Any malignant foci are not seen, within the teratomatous components.
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